The Potential Dangers of Sucralose (Splenda?) - Articles: "Is Splenda Really As Safe As They Claim It to Be?
As of 2006, only six human trials have been published on Splenda (sucralose). Of these six trials, only two of the trials were completed and published before the FDA approved sucralose for human consumption. The two published trials had a grand total of 36 total human subjects.
36 people sure doesn't sound like many, but wait, it gets worse, only 23 total were actually given sucralose for testing and here is the real killer:
The longest trial at this time had lasted only four days and looked at sucralose in relation to tooth decay, not human tolerance."